Sonographic abnormality of the substantia nigra in melanoma patients.
Identifieur interne : 000774 ( Main/Exploration ); précédent : 000773; suivant : 000775Sonographic abnormality of the substantia nigra in melanoma patients.
Auteurs : Jost-Julian Rumpf [Allemagne] ; David Weise ; Christopher Fricke ; Tino Wetzig ; Jan-Christoph Simon ; Joseph ClassenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- pathology : Melanoma.
- ultrasonography : Melanoma, Substantia Nigra.
- Adult, Aged, Aged, 80 and over, Anatomy, Cross-Sectional, Female, Humans, Male, Middle Aged, Ultrasonography, Doppler, Transcranial.
Abstract
Evidence derived from large epidemiological studies suggests an association between Parkinson's disease (PD) and malignant melanoma. Transcranial sonography of the midbrain reveals an extended echogenic substantia nigra (SN) area in a high proportion of patients with PD. This characteristic, in the context of PD, may signal degeneration of dopaminergic nigrostriatal projection neurons. Demonstration of an increased prevalence of abnormal echogenic SN in melanoma patients could add weight to the hypothesis of an underlying common pathogenic pathway of both diseases.
DOI: 10.1002/mds.25233
PubMed: 23114984
Affiliations:
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Le document en format XML
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<term>Melanoma (pathology)</term>
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<front><div type="abstract" xml:lang="en">Evidence derived from large epidemiological studies suggests an association between Parkinson's disease (PD) and malignant melanoma. Transcranial sonography of the midbrain reveals an extended echogenic substantia nigra (SN) area in a high proportion of patients with PD. This characteristic, in the context of PD, may signal degeneration of dopaminergic nigrostriatal projection neurons. Demonstration of an increased prevalence of abnormal echogenic SN in melanoma patients could add weight to the hypothesis of an underlying common pathogenic pathway of both diseases.</div>
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